Aphrodite Kapurniotu : rechercher sur Z-Library

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Articles (51)
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1

Cytotoxicity of Insulin within its Self-assembly and Amyloidogenic Pathways

Stefan Grudzielanek, Aleksandra Velkova, Anuj Shukla, Vytautas Smirnovas, Marianna Tatarek-Nossol, Heinz Rehage, Aphrodite Kapurniotu, Roland Winter

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2007

2

Amyloidogenicity and cytotoxicity of islet amyloid polypeptide

Aphrodite Kapurniotu

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2001

3

Ein IAPP-Mimetikum blockiert die zytotoxische Aggregation von Aβ – die Kreuzunterdrückung der Amyloidtoxizität von Aβ und IAPP deutet auf einen molekularen Zusammenhang zwischen Alzheimer-Krankheit und Typ-II-Diabetes hin

Li-Mei Yan, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto, Aphrodite Kapurniotu

Journal:

Angewandte Chemie

Année:

2007

Langue:

german

Fichier:

PDF, 1.02 MB

german, 2007

4

Amyloid-Kreuzwechselwirkung zur Inhibierung der Proteinaggregation, nicht aber der Proteinfunktion: Inhibierung der Insulinaggregation im nanomolaren Bereich durch ein IAPP-Mimetikum

Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto, Aphrodite Kapurniotu

Journal:

Angewandte Chemie

Année:

2008

Langue:

german

Fichier:

PDF, 829 KB

german, 2008

5

Hot-Spot-Regionen der Aβ-IAPP-Wechselwirkungsdomänen als hochaffine Bindungsstellen bei Kreuz- und Selbstassoziation

Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank, Aphrodite Kapurniotu

Journal:

Angewandte Chemie

Année:

2010

Langue:

german

Fichier:

PDF, 711 KB

german, 2010

6

Protein Misfolding Diseases. Current and Emerging Principles and Therapies. Wiley Series in Protein and Peptide Science. Herausgegeben von Marina Ramirez-Alvarado, Jeffery W. Kelly und Christopher M. Dobson.

Aphrodite Kapurniotu

Journal:

Angewandte Chemie

Année:

2011

Langue:

german

Fichier:

PDF, 365 KB

german, 2011

7

Terminierung des Amyloid-Reißverschlusses durch Design

Prof. Dr. Aphrodite Kapurniotu

Journal:

Angewandte Chemie

Année:

2011

Langue:

german

Fichier:

PDF, 503 KB

german, 2011

8

IAPP Mimic Blocks Aβ Cytotoxic Self-Assembly: Cross-Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes

Li-Mei Yan, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto, Aphrodite Kapurniotu

Journal:

Angewandte Chemie International Edition

Année:

2007

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2007

9

Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto, Aphrodite Kapurniotu

Journal:

Angewandte Chemie International Edition

Année:

2008

Langue:

english

Fichier:

PDF, 830 KB

english, 2008

10

Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank, Aphrodite Kapurniotu

Journal:

Angewandte Chemie International Edition

Année:

2010

Langue:

english

Fichier:

PDF, 751 KB

english, 2010

11

Protein Misfolding Diseases. Current and Emerging Principles and Therapies. Wiley Series in Protein and Peptide Science. Edited by Marina Ramirez-Alvarado, Jeffery W. Kelly, and Christopher M. Dobson.

Aphrodite Kapurniotu

Journal:

Angewandte Chemie International Edition

Année:

2011

Langue:

english

Fichier:

PDF, 363 KB

english, 2011

12

Terminating the Amyloid Zipper by Design

Prof. Dr. Aphrodite Kapurniotu

Journal:

Angewandte Chemie International Edition

Année:

2011

Langue:

english

Fichier:

PDF, 494 KB

english, 2011

13

Cross-Amyloid Interaction of Aβ and IAPP at Lipid Membranes

Janine Seeliger, Dr. Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Dr. Katrin Weise, Erika Andreetto, Prof. Dr. Metin Tolan, Prof. Dr. Aphrodite Kapurniotu, Prof. Dr. Roland Winter

Journal:

Angewandte Chemie International Edition

Année:

2012

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2012

14

Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity

Erika Andreetto, Dr. Li-Mei Yan, Dr. Andrea Caporale, Prof. Aphrodite Kapurniotu

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 484 KB

english, 2011

15

Shedding Light on Alzheimer's β-Amyloid Aggregation with Chemical Tools

Prof. Dr. Aphrodite Kapurniotu

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 276 KB

english, 2012

16

Cover Picture: Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity (ChemBioChem 9/2011)

Erika Andreetto, Dr. Li-Mei Yan, Dr. Andrea Caporale, Prof. Aphrodite Kapurniotu

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 953 KB

english, 2011

17

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

Daniel Sellin, Li-Mei Yan, Aphrodite Kapurniotu, Roland Winter

Journal:

Biophysical Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 932 KB

english, 2010

18

Targeting α-Synuclein in Parkinson's Disease

Aphrodite Kapurniotu

Journal:

Chemistry & Biology

Année:

2004

Langue:

english

Fichier:

PDF, 98 KB

english, 2004

19

Inhibition of hIAPP Amyloid-Fibril Formation and Apoptotic Cell Death by a Designed hIAPP Amyloid- Core-Containing Hexapeptide

Marianna Tatarek-Nossol, Li-Mei Yan, Anke Schmauder, Konstantinos Tenidis, Gunilla Westermark, Aphrodite Kapurniotu

Journal:

Chemistry & Biology

Année:

2005

Langue:

english

Fichier:

PDF, 612 KB

english, 2005

20

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP)

Monika Krampert, Jürgen Bernhagen, Jürgen Schmucker, Anita Horn, Anke Schmauder, Herwig Brunner, Wolfgang Voelter, Aphrodite Kapurniotu

Journal:

Chemistry & Biology

Année:

2000

Langue:

english

Fichier:

PDF, 877 KB

english, 2000

21

Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt

Athanasios Kazantzis, Michaela Waldner, John W. Taylor, Aphrodite Kapurniotu

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 487 KB

english, 2002

22

Rational design, conformational studies and bioactivity of highly potent conformationally constrained calcitonin analogues

Aphrodite Kapurniotu, Rakez Kayed, John W. Taylor, Wolfgang Voelter

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 762 KB

english, 1999

23

Conformational Restriction via Cyclization in β-Amyloid Peptide Aβ(1-28) Leads to an Inhibitor of Aβ(1-28) Amyloidogenesis and Cytotoxicity

Aphrodite Kapurniotu, Andreas Buck, Marco Weber, Anke Schmauder, Thomas Hirsch, Jürgen Bernhagen, Marianna Tatarek-Nossol

Journal:

Chemistry & Biology

Année:

2003

Langue:

english

Fichier:

PDF, 470 KB

english, 2003

24

An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

Vasan, Sara, Zhang, Xin, Zhang, Xini, Kapurniotu, Aphrodite, Bernhagen, Jürgen, Teichberg, Saul, Basgen, John, Wagle, Dilip, Shih, David, Terlecky, Ihor

Journal:

Année:

1996

Fichier:

PDF, 952 KB

1996

25

Cross-Amyloid Interaction of Aβ and IAPP at Lipid Membranes

Janine Seeliger, Dr. Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Dr. Katrin Weise, Erika Andreetto, Prof. Dr. Metin Tolan, Prof. Dr. Aphrodite Kapurniotu, Prof. Dr. Roland Winter

Journal:

Angewandte Chemie

Année:

2012

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2012

26

Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity

Hongqi Lue, Aphrodite Kapurniotu, Günter Fingerle-Rowson, Thierry Roger, Lin Leng, Michael Thiele, Thierry Calandra, Richard Bucala, Jürgen Bernhagen

Journal:

Cellular Signalling

Année:

2006

Langue:

english

Fichier:

PDF, 1007 KB

english, 2006

27

Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

Aphrodite Kapurniotu, Jürgen Bernhagen, Norma Greenfield, Yousef Al-Abed, Saul Teichberg, Rainer W. Frank, Wolfgang Voelter, Richard Bucala

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 618 KB

english, 1998

28

Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF

Robert Kleemann, Aphrodite Kapurniotu, Ralf Mischke, Jürgen Held, Jürgen Bernhagen

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 855 KB

english, 1999

29

Disulfide analysis reveals a role for macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase

Robert Kleemann, Aphrodite Kapurniotu, Rainer W Frank, André Gessner, Ralf Mischke, Oliver Flieger, Stefan Jüttner, Herwig Brunner, Jürgen Bernhagen

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 386 KB

english, 1998

30

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in Vitro

Rakez Kayed, Jürgen Bernhagen, Norma Greenfield, Khuloud Sweimeh, Herwig Brunner, Wolfgang Voelter, Aphrodite Kapurniotu

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 440 KB

english, 1999

31

Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties

Konstantinos Tenidis, Michaela Waldner, Jürgen Bernhagen, Wolfgang Fischle, Michael Bergmann, Marco Weber, Marie-Luise Merkle, Wolfgang Voelter, Herwig Brunner, Aphrodite Kapurniotu

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 600 KB

english, 2000

32

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

Aphrodite Kapurniotu, Anke Schmauder, Konstantinos Tenidis

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 375 KB

english, 2002

33

Structure activity studies of the cytokine macrophage migration inhibitory factor (MIF) reveal a critical role for its car☐y terminus

Ralf Mischke, André Gessner, Aphrodite Kapurniotu, Stefan Jüttner, Robert Kleemann, Herwig Brunner, Jürgen Bernhagen

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 749 KB

english, 1997

34

Specific reduction of insulin disulfides by macrophage migration inhibitory factor (MIF) with glutathione and dihydrolipoamide: potential role in cellular redox processes

Robert Kleemann, Ralf Mischke, Aphrodite Kapurniotu, Herwig Brunner, Jürgen Bernhagen

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 162 KB

english, 1998

35

The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

Pester, Oxana, Barrett, Paul J., Hornburg, Daniel, Hornburg, Philipp, Pröbstle, Rasmus, Widmaier, Simon, Kutzner, Christoph, Dürrbaum, Milena, Kapurniotu, Aphrodite, Sanders, Charles R., Scharnagl, Ch

Journal:

Journal of the American Chemical Society

Année:

2013

Langue:

english

Fichier:

PDF, 2.31 MB

english, 2013

36

Strategien zur Inhibition der Protein-aggregation bei Amyloidkrankheiten

Kapurniotu, Aphrodite

Journal:

Année:

2012

Langue:

german

Fichier:

PDF, 311 KB

german, 2012

37

A Novel Drug-Eluting Stent Coated With an Integrin-Binding Cyclic Arg-Gly-Asp Peptide Inhibits Neointimal Hyperplasia by Recruiting Endothelial Progenitor Cells

Rüdiger Blindt, Felix Vogt, Irina Astafieva, Christian Fach, Mihail Hristov, Nicole Krott, Berthold Seitz, Aphrodite Kapurniotu, Connie Kwok, Manfred Dewor, Anja-Katrin Bosserhoff, Jürgen Bernhagen, P

Journal:

Journal of the American College of Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2006

38

Development of Accessible Peptidic Tool Compounds To Study the Phosphatase PTP1B in Intact Cells

Meyer, Christoph, Hoeger, Birgit, Temmerman, Koen, Tatarek-Nossol, Marianna, Pogenberg, Vivian, Bernhagen, Jürgen, Wilmanns, Matthias, Kapurniotu, Aphrodite, Köhn, Maja

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 909 KB

english, 2014

39

Designed Hairpin Peptides Interfere with Amyloidogenesis Pathways: Fibril Formation and Cytotoxicity Inhibition, Interception of the Preamyloid State

Huggins, Kelly N. L., Bisaglia, Marco, Bubacco, Luigi, Tatarek-Nossol, Marianna, Kapurniotu, Aphrodite, Andersen, Niels H.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 3.25 MB

english, 2011

40

Contribution of Conformationally Constrained Calcitonin (Ct) Analogs to the Understanding of the Structural and Conformational Requirements of Calcitonin Bioactivity and to the Design of Potent Agonists

Kapurniotu, Aphrodite

Journal:

Current Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 645 KB

english, 2004

41

Side-Chain Lactam-Bridge Conformational Constraints Differentiate the Activities of Salmon and Human Calcitonins and Reveal a New Design Concept for Potent Calcitonin Analogues

Taylor, John W., Jin, Qian K., Sbacchi, Massimo, Wang, Lu, Belfiore, Piero, Garnier, Martine, Kazantzis, Athanasios, Kapurniotu, Aphrodite, Zaratin, Paola F., Scheideler, Mark A.

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 151 KB

english, 2002

42

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

Sivanesam, Kalkena, Shu, Irene, Huggins, Kelly N. L., Tatarek-Nossol, Marianna, Kapurniotu, Aphrodite, Andersen, Niels H.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 658 KB

english, 2016

43

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

Bakou, Maria, Hille, Kathleen, Kracklauer, Michael, Spanopoulou, Anna, Frost, Christina V., Malideli, Eleni, Yan, Li-Mei, Caporale, Andrea, Zacharias, Martin, Kapurniotu, Aphrodite

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.71 MB

english, 2017

44

LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF

Klasen, Christina, Ziehm, Tamar, Huber, Michael, Asare, Yaw, Kapurniotu, Aphrodite, Shachar, Idit, Bernhagen, Jürgen, El Bounkari, Omar

Journal:

Cellular Signalling

Année:

2018

Langue:

english

Fichier:

PDF, 5.97 MB

english, 2018

45

Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide

Rezaei-Ghaleh, Nasrollah, Andreetto, Erika, Yan, Li-Mei, Kapurniotu, Aphrodite, Zweckstetter, Markus, Santos, Janine

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2011

46

Macrophage Migration Inhibitory Factor Increases Neuronal Delayed Rectifier K + Current

Matsuura, Tomokazu, Sun, Chengwen, Leng, Lin, Kapurniotu, Aphrodite, Bernhagen, Jürgen, Bucala, Richard, Martynyuk, Anatoly E., Sumners, Colin

Journal:

Journal of Neurophysiology

Année:

2006

Langue:

english

Fichier:

PDF, 250 KB

english, 2006

47

Blocking inflammasome activation caused by β-amyloid peptide (Aβ) and islet amyloid polypeptide (IAPP) through an IAPP mimic

Aftabizadeh, Maryam, Tatarek-Nossol, Marianna, Andreetto, Erika, El Bounkari, Omar, Kipp, Markus, Beyer, Cordian, Latz, Eicke, Bernhagen, Juergen, Kapurniotu, Aphrodite

Journal:

ACS Chemical Neuroscience

Année:

2019

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2019

48

Peptide‐based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration

Armiento, Valentina, Spanopoulou, Anna, Kapurniotu, Aphrodite

Journal:

Angewandte Chemie

Année:

2019

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2019

49

Peptide-based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration

Armiento, Valentina, Spanopoulou, Anna, Kapurniotu, Aphrodite

Journal:

Angewandte Chemie International Edition

Année:

2019

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2019

50

Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs

Sinitski, Dzmitry, Gruner, Katrin, Brandhofer, Markus, Kontos, Christos, Winkler, Pascal, Reinstädler, Anja, Bourilhon, Priscila, Xiao, Zhangping, Cool, Robbert H., Kapurniotu, Aphrodite, Dekker, Fran

Journal:

Journal of Biological Chemistry

Année:

2019

Fichier:

PDF, 2.71 MB

2019